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BioMed Research International
Volume 2013, Article ID 697051, 13 pages
Research Article

In Silico Screening and Molecular Dynamics Simulation of Disease-Associated nsSNP in TYRP1 Gene and Its Structural Consequences in OCA3

1School of Bio Sciences and Technology (SBST), Bioinformatics Division, Vellore Institute of Technology University, Vellore, Tamil Nadu 632014, India
2Human Genetics Foundation, Torino, Via Nizza 52, 10126 Torino, Italy

Received 20 April 2013; Revised 23 May 2013; Accepted 23 May 2013

Academic Editor: Claudio M. Soares

Copyright © 2013 Balu Kamaraj and Rituraj Purohit. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The consequences upon mutations were clearly observed in the atomic density distribution plot. There was a significant change in density distribution in mutant as compared to the native. Native structure shows highest atomic density distribution of 41.9 nm-3 but in mutant (R326H & R356Q) structures showed 52.2 and 52.3 nm-3 respectively. It was further indicate that native has more flexibility than mutant (R326H & R356Q) structures.

  1. Supplementary Figure