iEzy-Drug: A Web Server for Identifying the Interaction between Enzymes and Drugs in Cellular Networking
Figure 1
A schematic drawing to illustrate how to use Chou’s distorted key theory to develop peptide drugs against HIV/AIDS. (a) shows a good fitting and binding of a peptide to the active site of HIV protease right before it is cleaved by the enzyme. (b) shows that the peptide has become a noncleavable one after its scissile bond is modified although it can still tightly bind to the active site. Such a modified peptide, or ‘‘distorted key”, will automatically become an inhibitor candidate against HIV protease.
