Characterization of C-S Lyase from C. diphtheriae: A Possible Target for New Antimicrobial Drugs

Figure 4

Sequence alignment of C-S lyases. The target residues for mutational analysis are highlighted in gray. The arrow above the sequences indicates the PLP-binding lysine. The C-S lyases used in this alignment (UniProt accession numbers) and their sources are Q6NFZ9, Corynebacterium diphtheriae NCTC 13129; Q46061, Corynebacterium glutamicum; M1NUD7, Corynebacterium halotolerans; C0VUP4, Corynebacterium glucuronolyticum; A6BMJ3, Streptococcus anginosus IMU102; Q8DST5, Streptococcus mutans; Q56257, Treponema denticola ATCC 3540. All sequence alignments were carried out using the ClustalW program.