A Systems’ Biology Approach to Study MicroRNA-Mediated Gene Regulatory Networks

Figure 4

p21 expression regulated by cooperative miRNAs for different cellular processes. The associations of the miRNAs with these cellular processes were derived from GO terms of their TFs. A miRNA was supposed to be expressed (in bold black font) in a cellular process only if its TF is related to the corresponding GO term of this process. The p21 expression levels are computed for each process with (w)/without (wo) considering the cooperative effect among the p21 targeting miRNAs.