Research Article

Enhanced Production of Acarbose and Concurrently Reduced Formation of Impurity C by Addition of Validamine in Fermentation of Actinoplanes utahensis ZJB-08196

Figure 1

Time course of acarbose accumulation, maltose and glucose consumption, cell growth, and impurity C formation during batch cultivation of A. utahensis ZJB-08196 at 28°C and 200 rpm for 216 h in fermentation medium. Symbols: ■: acarbose; ▲: impurity C; •: DCW; □: maltose; ○: glucose; △: osmolality.
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