Figure 8: In vitro release profile of GEM from various nanocarriers under physiological pH (pH 7.4). Lyophilized formulations were resuspended in PBS solution and filled inside dialysis membrane bag with molecular weight cutoff of 12 K Da (Sigma, USA). The membrane bags were placed in 50 mL of at PBS pH 7.4 medium maintaining the system at °C with continuous slow magnetic stirring at 300 rpm. At specific time intervals, 0.5 mL aliquots of dissolution medium were withdrawn and analyzed for GEM content. Results are represented as mean S.D ().