Research Article
Formulation Development and Stability Studies of Norfloxacin Extended-Release Matrix Tablets
Table 5
Coefficients of determination (
) obtained from dissolution of norfloxacin uncoated formulations according to different mathematical models.
| Formulation | Zero order | First order | Higuchi | Korsmeyer-Peppas | | | | | |
| HPMC K100LV 20% | 0.9794 | 0.9247 | 0.9685 | 0.9952 | 0.9623 | HPMC K100LV 30% | 0.9794 | 0.8538 | 0.9681 | 0.9985 | 0.9761 | HPMC K4M 20% | 0.9943 | 0.9916 | 0.9604 | 0.9963 | 0.7115 | HPMC K4M 30% | 0.9834 | 0.9954 | 0.9801 | 0.9986 | 0.6593 | PEO N60K 20% | 0.9976 | 0.9302 | 0.9372 | 0.9994 | 0.9485 | PEO N60K 30% | 0.9978 | 0.9513 | 0.9127 | 0.9990 | 1.0027 | PEO 301 20% | 0.9978 | 0.9591 | 0.9180 | 0.9978 | 0.8900 | PEO 301 30% | 0.9978 | 0.9795 | 0.9308 | 0.9971 | 0.8771 |
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