Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes

Table 1

Demographics and laboratory data of patients with diabetes with and without lower leg ulcers. 𝑃 values for differences between patients with and without ulcers were performed by linear regression, corrected for age.

	𝑛	Normal range	Diabetes; without ulcers; (mean ± s.d)	Diabetes; with ulcers; (mean ± s.d)	𝑃 value; by LR; (age as covariate)
Age	72	—	59.82 ± 16.31	65.56 ± 15.15	0.46
Gender	72	—	64% male	64% male	—
Type of diabetes	72	—	82% Type 2	83% Type 2	—
Total PC (%)	72	70–180	127.1 ± 34.0	103.3 ± 22.7	<0.001
Free PS (%)	60	60–160	124.7 ± 22.4	108.4 ± 37.8	0.056
Fibrinogen (g/L)	60	5.9–11.8	11.6 ± 2.23	12.3 ± 2.6	0.76
INR	60	0.8–1.2	0.97 ± 0.08	1.02 ± 0.08	0.003
Prothrombin time (sec)	60	13–15	13.33 ± 0.83	13.90 ± 0.82	0.026
APTT (sec)	60	26–36	27.28 ± 2.512	28.75 ± 2.75	0.12
CRP (mg/L)	32	<47	61.0 ± 62.5	211.4 ± 262.0	0.022
HbA1c (%)	54	4–6	6.96 ± 1.42	7.15 ± 1.79	0.61
sEPCR (ng/mL)	54	—	25.0 ± 15.9	28.0 ± 20.1	0.77