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BioMed Research International
Volume 2013 (2013), Article ID 719858, 11 pages
Research Article

Alantolactone Induces Apoptosis in HepG2 Cells through GSH Depletion, Inhibition of STAT3 Activation, and Mitochondrial Dysfunction

1Central Research Laboratory, Jilin University Bethune Second Hospital, Changchun 130041, China
2Department of Zoology, University of the Punjab, Quaid-e-Azam Campus, Lahore 54590, Pakistan
3Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Qianjin Street, Changchun 130012, China

Received 2 August 2012; Revised 24 October 2012; Accepted 24 October 2012

Academic Editor: D. M. Clarke

Copyright © 2013 Muhammad Khan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Purity of Alantolactone (99.12%) was determined by HPLC. HPLC were performed on a Waters XTerra C18 (4.6 mm×150 mm, 5μm). The mobile phase consisted of (A) acetonitrile containing 0.2% acetic acid and (B) 0.2% acetic acid in water with gradient elution: 0–15 min, 10–70% B; 15–30 min, 70–80% B; The temperature of autosampler was maintained at 25°C and detection wavelength was 254 nm.

  1. Supplementary Figure