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BioMed Research International
Volume 2013, Article ID 720514, 9 pages
Review Article

Metabolomics Application in Maternal-Fetal Medicine

1NICU, Puericulture Institute and Neonatal Section, AOU and University of Cagliari, 09124 Cagliari, Italy
2Department of Biomedical Science, University of Cagliari, 09124 Cagliari, Italy
3Department of Woman, Mother and Neonate, Buzzi Hospital, Biomedical and Clinical Sciences School of Medicine, University of Milan, 20122 Milan, Italy
4Department of Obstetrics and Gynecology and Human Reproduction Physiopathology, University of Cagliari, 09124 Cagliari, Italy

Received 19 April 2013; Revised 10 May 2013; Accepted 13 May 2013

Academic Editor: Kaei Nasu

Copyright © 2013 Vassilios Fanos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Metabolomics in maternal-fetal medicine is still an “embryonic” science. However, there is already an increasing interest in metabolome of normal and complicated pregnancies, and neonatal outcomes. Tissues used for metabolomics interrogations of pregnant women, fetuses and newborns are amniotic fluid, blood, plasma, cord blood, placenta, urine, and vaginal secretions. All published papers highlight the strong correlation between biomarkers found in these tissues and fetal malformations, preterm delivery, premature rupture of membranes, gestational diabetes mellitus, preeclampsia, neonatal asphyxia, and hypoxic-ischemic encephalopathy. The aim of this review is to summarize and comment on original data available in relevant published works in order to emphasize the clinical potential of metabolomics in obstetrics in the immediate future.