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Population study | Material | Metabolomic analysis | Main results | Significance/take-home messages | Reference | Author, year |
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9 SGA cases versus 8 controls | Placenta villous explants | UPLC-MS | 574 metabolites were significantly different between SGA and controls; 49% of metabolites of interest were the same for SGA explant cultured under hypoxic conditions and controls cultured under normoxic conditions Changes in phospholipids, essential amino acids (tryptophan, methionine, and phenylalanine) concentrations | Metabolomics might predict SGA | [11] | Horgan et al., 2010 |
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11 uncomplicated term pregnancies | Placenta villous explants | GC-MS | Cultured in 1%, 6%, and 20% oxygen. Differences in 2-deoxyribose, threitol/erythritol, hexadecanoic acid | Metabolomics can be applied to placenta studies and could help in detecting hypoxia | [10] | Heazell et al., 2008 |
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6 cases of preeclampsia versus 6 controls | Villous trophoblast | UPLC-MS | 47 metabolites in preeclampsia-derived media cultured under normoxic conditions showed similarities to that of uncomplicated pregnancies cultured under hypoxic conditions. Alterations in glutamate and glutamine, leukotrienes and prostaglandins, kynurenine metabolism | Metabolomics might predict preeclampsia of placental origin developed due to hypoxia | [4] | Dunn et al., 2009 |
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8 cases of labor/Cesarean section at 3100 m versus 8 controls with labor/Cesarean section delivery at sea level | Placenta | 1H NMR, 31P NMR | At sea level: metabolic markers of oxidative stress, increased glycolysis, elevated cholesterol, and free amino acids. At 3100 m: metabolic profiles with adaptation to chronic hypoxia, decreased reliance on anaerobic glycolysis; presence of concentrations of stored energy potential (phosphocreatine), antioxidants (taurine, inositol), and low free amino acid concentrations | Metabolomics might help identify subjects under hypoxic stress (chronic hypoxic preconditioning state versus acute ischemic/hypoxic insult) | [6] | Tissot van Patot et al., 2010 |
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