CXCR1/CXCR2 Antagonism Is Effective in Pulmonary Defense against Klebsiella pneumoniae Infection
Figure 1
Treatment with the ELR-CXC chemokine antagonist G31P reduces pulmonary neutrophil responses in guinea pigs with Klebsiella pneumoniae. Guinea pigs were challenged with Klebsiella pneumoniae and treated with G31P. The airway neutrophil responses were assessed from differential counts of cells recovered by bronchoalveolar lavage (BAL). The airway (BAL fluid) levels of myeloperoxidase (MPO), as surrogate measurements of neutrophilic inflammation, were assessed using a chromogenic assay. The G31P treatments reduced each of these indicators of neutrophilic inflammation close to normal. This experiment was repeated three times; the data depicted are representative of each group.
