Clinical Study
The Role of PTPN22 C1858T Gene Polymorphism in Diabetes Mellitus Type 1: First Evaluation in Greek Children and Adolescents
Table 3
The distribution of PTPN22 C1858T polymorphism in patients with T1DM according to studied parameters.
| | | Allele | Genotype | | | C | T | CC | CT | TT | CT + TT | | | Frequency (%) |
| | Gender | | | | | | | | (male/female) (73/57) | 136/109 (93.2/95.8) | 10/5 (6.8/4.4) | 64/52 (87.7/91.2) | 8/5 (11.0/8.8) | 1/0 (1.4/0) | 9/5
(12.3/8.8) | | 0.436 | 0.613 | 0.580 | | Age at onset | | | | | | | | (10/10 years) (88/42) | 166/79 (94.3/94) | 10/5
(5.7/6) | 79/37 (89.8/88.1) | 8/5 (9.1/11.9) | 1/0 (1.1/0) | 9/5 (10.2/11.9) | | 1.000 | 0.701 | 0.769 | | Tanner stage at diagnosis | | | | | | | | (I/II–V) (99/31) | 188/57 (94.9/91.9) | 10/5 (5.1/8.1) | 90/26 (90.9/83.9) | 8/5 (8.1/16.1) | 1/0 (1.0/0) | 9/5
(9.1/16.1) | | 0.361 | 0.373 | 0.320 | | Ketoacidosis at onset | | | | | | | | (+/−) (104/26) | 195/50 (93.8/96.2) | 13/2 (6.3/3.8) | 92/24 (88.5/92.3) | 11/2 (10.6/7.7) | 1/0 (1.0/0) | 12/2 (11.5/7.7) | | 0.742 | 0.796 | 0.735 | | HT | | | | | | | | (+/−) (27/103) | 49/196 (90.7/95.1) | 5/10 (9.3/4.9) | 23/93 (85.2/90.3) | 3/10 (11.1/9.7) | 1/0 (3.7/0) | 4/10 (14.8/9.7) | | 0.206 | 0.141 | 0.488 | | Familiar history of T1DM | | | | | | | | (+/−) (19/111) | 37/208 (97.4/93.7) | 1/14
(2.1/6.3) | 18/98 (94.78/88.3) | 1/12 (5.3/10.8) | 0/1 (0/0.9) | 1/13 (5.3/11.7) | | 0.704 | 0.689 | 0.692 |
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