Ubiquitin Ligase Cbl-b Is Involved in Icotinib (BPI-2009H)-Induced Apoptosis and G1 Phase Arrest of EGFR Mutation-Positive Non-Small-Cell Lung Cancer

Figure 2

Icotinib inhibited human NSCLC cell proliferation. HCC827 and A549 cells were exposed to icotinib (1 nM–100 μM) for 48 h, and cell viability was determined by MTT assay. Data are the mean ± SD of at least three independent experiments performed in triplicate.