BioMed Research International / 2013 / Article / Fig 5

Research Article

Ubiquitin Ligase Cbl-b Is Involved in Icotinib (BPI-2009H)-Induced Apoptosis and G1 Phase Arrest of EGFR Mutation-Positive Non-Small-Cell Lung Cancer

Figure 5

Icotinib regulated phosphorylation of EGFR, Akt, and ERK. Western blot analysis of EGFR, Akt, and ERK protein expression in HCC827 cells treated with 0.01–1 μmol/L icotinib. β-Actin was used as the internal control.