Aldose Reductase Inhibitory Activity of Compounds from  Zea mays L.

Table 3

Inhibitory effects of the compounds on the galactitol accumulation in rat lenses and erythrocytes.

Compounds	Galactitol content (μM)^a in rat erythrocyte [inhibition %]	Galactitol content μg/lens wet weight (g)^b [inhibition %]
Galactose free	0.98	—
Control	22.80	844.05±74.02
Quercetinc	16.15 [30.48%]	448.81±69.43 [46.82%]
Hirsutrin (6)	15.70 [32.54%]	558.92±89.12 [33.78%]
3′-methoxyhirsutrin (7)	20.19 [11.96%]	828.35±73.27 [1.86%]

^aErythrocyte was incubated in a Krebs-Ringer bicarbonate buffer containing 30 mM galactose and in the presence or absence of 50 μg/mL compounds. ^bMean ± standard deviation of triplication analysis of rat lens with compounds at a concentration 5 μg/mL. ^cQuercetin were used as positive control.