BioMed Research International / 2013 / Article / Fig 5

Research Article

CD59 Underlines the Antiatherosclerotic Effects of C-Phycocyanin on Mice

Figure 5

CDK4 mRNA levels in different groups of mice. (a) CDK4 mRNA levels by in situ hybridization ( ). The positive cell nucleus was dyed brownish yellow. The color in aortic plaque arose from smooth muscle cells was dark and CDK4 mRNA levels were high in control group. In C-PC treatment group and CD59 transfection group, the nucleus color was lighter and brownish-yellow granules were less than those in control group. Moreover, the color was the lightest and staining intensity was the weakest in C-PC+CD59 synergy group. (A) Control group, (B) C-PC treatment group, (C) CD59 transfection group, and (D) C-PC+CD59 synergy group. (b) IOD values of different groups of mice. * , ** versus control group. IOD values represent the levels of protein expression. Compared with the control group, the IOD values in CD59 or C-PC treated groups were decreased and the differences were significant (* ). The IOD values were further enhanced in C-PC and CD59 synergy group and the differences were very significant (** ).

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