Levels of Key Enzymes of Methionine-Homocysteine Metabolism in Preeclampsia

Table 2

Frequencies of genotypes of the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR) gene in controls and preeclamptic patients.

Genotypes	Control patients (𝑛=32)	Preeclampsia patients (𝑛=16)	P value	OR	(95% Conf. interval)
MTHFR C677T
Wild Type	9 (28.1%)	3 (18.8%)	0.725	1.69	[0.389–7.400]
Heterozygote/homozygote	23 (71.9%)	13 (81.2%)
MTHFR A1268C
Wild Type	4 (12.5%)	6 (37.5%)	0.063	0.238	[0.055–1.022]
Heterozygote/homozygote	28 (87.5%)	10 (62.5%)
MTR A2756G
Wild Type	16 (50.0%)	10 (62.5%)	0.542	0.6	[0.176–2.046]
Heterozygote/homozygote	16 (50.0%)	6 (37.5%)

MTHFR C677T: wild type (C/C), heterozygote (C/T) and homozygote (T/T); MTHFR A1268C: wild type (A/A), heterozygote (A/C), homozygote (C/C); MTR A2756G: wild type (A/A), heterozygote (A/G), homozygote (G/G). Data show the number of control and preeclamptic patients with or without the polymorphism. Statistical significance was assessed using Fisher's exact test.