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BioMed Research International
Volume 2013 (2013), Article ID 734137, 15 pages
The CULTEX RFS: A Comprehensive Technical Approach for the In Vitro Exposure of Airway Epithelial Cells to the Particulate Matter at the Air-Liquid Interface
1Cultex Laboratories GmbH, Feodor-Lynen-Straße 21, 30625 Hannover, Germany
2Halter Engineering GmbH, Huebstraße 16, 9100 Herisau, Switzerland
3Von der Hardt 16, 57392 Oberkirchen, Germany
Received 8 October 2012; Revised 23 November 2012; Accepted 16 December 2012
Academic Editor: Abderrahim Nemmar
Copyright © 2013 Michaela Aufderheide et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [18 citations]
The following is the list of published articles that have cited the current article.
- David Thorne, and Jason Adamson, “A review of in vitro cigarette smoke exposure systems,” Experimental and Toxicologic Pathology, 2013.
- Dirk Steinritz, Niklas Möhle, Christine Pohl, Mirko Papritz, Bernhard Stenger, Annette Schmidt, Charles James Kirkpatrick, Horst Thiermann, Richard Vogel, Sebastian Hoffmann, and Michaela Aufderheide, “Use of the Cultex® Radial Flow System as an in vitro exposure method to assess acute pulmonary toxicity of fine dusts and nanoparticles with special focus on the intra- and inter-laboratory reproducibility,” Chemico-Biological Interactions, 2013.
- Felicia Goh, Janet G Shaw, Santiyagu M Savarimuthu Francis, Annalicia Vaughan, Leanne Morrison, Vandana Relan, Henry M Marshall, Annette G Dent, Phoebe E O’Hare, Amy Hsiao, Rayleen V Bowman, Kwun M Fong, and Ian A Yang, “Personalizing and targeting therapy for COPD – the role of molecular and clinical biomarkers,” Expert Review of Respiratory Medicine, pp. 1–13, 2013.
- Jose Zavala, Kim Lichtveld, Seth Ebersviller, Johnny L. Carson, Glenn W. Walters, Ilona Jaspers, Harvey E. Jeffries, Kenneth G. Sexton, and William Vizuete, “The Gillings Sampler – An Electrostatic Air Sampler as an Alternative Method for Aerosol In Vitro Exposure Studies,” Chemico-Biological Interactions, 2014.
- Amanda J Hayes, and Shahnaz Bakand, “Toxicological perspectives of inhaled therapeutics and nanoparticles,” Expert Opinion on Drug Metabolism & Toxicology, pp. 1–15, 2014.
- Brandi N. Snyder-Talkington, Chunlin Dong, Xiangyi Zhao, Julian Dymacek, Dale W. Porter, Michael G. Wolfarth, Vincent Castranova, Yong Qian, and Nancy L. Guo, “Multi-walled carbon nanotube-induced gene expression in vitro: Concordance with in vivo studies,” Toxicology, 2014.
- Mariola J. Edelmann, Leslie A. Shack, Caitlin D. Naske, Keisha B. Walters, and Bindu Nanduri, “SILAC-Based Quantitative Proteomic Analysis of Human Lung Cell Response to Copper Oxide Nanoparticles,” Plos One, vol. 9, no. 12, 2014.
- Detlef Ritter, and Jan Knebel, “ Investigations of the Biological Effects of Airborne and Inhalable Substances by Cell-Based In Vitro Methods: Fundamental Improvements to the ALI Concept ,” Advances in Toxicology, vol. 2014, pp. 1–11, 2014.
- Amelie Tsoutsoulopoulos, Niklas Möhle, Michaela Aufderheide, Annette Schmidt, Horst Thiermann, and Dirk Steinritz, “Optimization of the CULTEX® Radial Flow System for in vitro investigation of lung damaging agents,” Toxicology Letters, 2015.
- Lynn E. Secondo, Nathan J. Liu, and Nastassja A. Lewinski, “ Methodological considerations when conducting in vitro , air–liquid interface exposures to engineered nanoparticle aerosols ,” Critical Reviews in Toxicology, pp. 1–38, 2016.
- Sandro Steiner, Shoaib Majeed, Gilles Kratzer, Julia Hoeng, and Stefan Frentzel, “A new fluorescence-based method for characterizing in vitro aerosol exposure systems,” Toxicology in Vitro, 2016.
- Shinkichi Ishikawa, and Shigeaki Ito, “Repeated whole cigarette smoke exposure alters cell differentiation and augments secretion of inflammatory mediators in air-liquid interface three-dimensional co-culture model of human bronchial tissue,” Toxicology in Vitro, 2016.
- Shahnaz Bakand, and Amanda Hayes, “Toxicological Considerations, Toxicity Assessment, and Risk Management of Inhaled Nanoparticles,” International Journal of Molecular Sciences, vol. 17, no. 6, pp. 929, 2016.
- Rudra Bhowmick, and Heather Gappa-Fahlenkamp, “Cells and Culture Systems Used to Model the Small Airway Epithelium,” Lung, 2016.
- Jose Zavala, Bridget O’Brien, Kim Lichtveld, Kenneth G. Sexton, Ivan Rusyn, Ilona Jaspers, and William Vizuete, “Assessment of biological responses of EpiAirway 3-D cell constructs versus A549 cells for determining toxicity of ambient air pollution,” Inhalation Toxicology, vol. 28, no. 6, pp. 251–259, 2016.
- Sonja Mülhopt, Marco Dilger, Silvia Diabaté, Christoph Schlager, Tobias Krebs, Ralf Zimmermann, Jeroen Buters, Sebastian Oeder, Thomas Wäscher, Carsten Weiss, and Hanns-Rudolf Paur, “Toxicity testing of combustion aerosols at the air-liquid interface with a self-contained and easy-to-use exposure system,” Journal of Aerosol Science, 2016.
- C. R. Svensson, S. S. Ameer, L. Ludvigsson, N. Ali, A. Alhamdow, M. E. Messing, J. Pagels, A. Gudmundsson, M. Bohgard, E. Sanfins, M. Kåredal, K. Broberg, and J. Rissler, “Validation of an air–liquid interface toxicological set-up using Cu, Pd, and Ag well-characterized nanostructured aggregates and spheres,” Journal of Nanoparticle Research, vol. 18, no. 4, 2016.
- Hubert Klus, Barbara Boenke-Nimphius, and Lutz Müller, “Cigarette Mainstream Smoke: The Evolution of Methods and Devices for Generation, Exposure and Collection,” Beiträge zur Tabakforschung International/Contributions to Tobacco Research, vol. 27, no. 4, 2016.