Figure 2: The SCIPIO trial targeting chronic heart failure. Autologous c-kit-positive cardiac stem cells (CSCs) were infused to the bypass graft of postinfarct patients. The trends of the left ventricular ejection fraction (LVEF) and the symptom categorized by the New York Heart Association (NYHA) functional classification are illustrated. Therapeutic effects lasted for more than two years without major adverse events. n: number of patients [19, 20].