Research Article
Moving toward Personalized Medicine in the Methadone Maintenance Treatment Program: A Pilot Study on the Evaluation of Treatment Responses in Taiwan
Table 5
Methadone maintenance dose and CYP2B6 and ABCB1 gene mutation relationships with R,S-methadone plasma concentrationa, b.
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R,S-Methadone concentration was natural-logarithmically transformed to achieve a normal distribution. bResults are from stepwise multiple linear regression analysis. Age, marital status, weight, current amphetamine use, treatment duration, drugs related to methadone-drug interactions, CYP2B6 G516T (*9), CYP2C19 G681A/C (*2), G636A (*3), C3402T (*17), ABCB1 C1236T, and C3435T were not significantly associated. Only variables significantly contributing to the models are displayed (variables selected using mixed stepwise regression); value for model: <0.0001. |