Structure and Antimicrobial Properties of Monensin A and Its Derivatives: Summary of the Achievements

Table 2

Characterisation and toxicity of monensin A.

Name	Monensin A, monensic acid
CAS name	2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-𝛽-methoxy-𝛼,𝛾,2,8-tetramethyl-1,6-dioxaspiro[4.5] decane-7-butyric acid
Molecular weight	670.87 g/mol
Molecular formula	C36H62O11
Composition	C 64,45%; H 9,32%; O 26,23%
Melting point	103–105°C (monohydrate)
Specific rotation	[𝛼]D = +47,7° (methanol)
Toxicity in animals (oral administration of the sodium salt) LD50:
Monkey	>160 mg/kg
Rabbit	42 mg/kg
Rat	29 mg/kg
Cattle	26 mg/kg
Swine	17 mg/kg
Dog	>10 mg/kg