Low pH Environmental Stress Inhibits LPS and LTA-Stimulated Proinflammatory Cytokine Production in Rat Alveolar Macrophages

<table>Effects of low pH stress on LTA-stimulated cytokine production in Ca<sup>2+</sup>-depleted alveolar macrophages (BAPTA-AM pretreatment). Isolated aMØs were exposed to LTA and BAPTA-AM alone (LTA + BAPTA-AM) or in combination with low pH stress (LTA + BAPTA-AM + pH). Cytokines produced were assessed by ELISA (CINC-1, MIP-2, and MCP-1) or cytotoxicity bioassay (TNF-<svg height="7.9499998" id="M138" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 9.7749996 7.9499998" width="9.7749996" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> LTA + BAPTA-AM versus LTA + BAPTA-AM + pH.</table>

BioMed Research International

fig7

Figure 7

Figure 7: Low pH Environmental Stress Inhibits LPS and LTA-Stimulated Proinflammatory Cytokine Production in Rat Alveolar Macrophages 