Environmental Lead Exposure Accelerates Progressive Diabetic Nephropathy in Type II Diabetic Patients

Table 2

Means of renal function during the 24-month observation period (𝑛=89).

Renal function	Low-normal BLB group	High-normal BLB group	𝑃 (95% CI)
(mL/min/1.73 m^2)	(𝑛=27)	(𝑛=62)
Month 0
Ccr	44.9 ± 10.8	41.1 ± 12.0	0.123 (−9.1–1.0)
D-GFR	42.4 ± 6.2	40.8 ± 7.1	0.300 (−1.5–4.8)
Month 6	(𝑛=27)	(𝑛=62)
Ccr	41.5 ± 15.2	33.1 ± 13.0	0.010 (−14.6–−2.1)
D-GFR	38.1 ± 9.2	32.9 ± 8.3	0.010 (−9.1–−1.3)
Month 12	(𝑛=27)	(𝑛=62)
Ccr	41.0 ± 19.2	26.2 ± 12.2	<0.001 (−21.6–−8.1)
D-GFR	36.6 ± 9.5	27.2 ± 8.9	<0.001 (−13.6–−5.2)
Month 18	(𝑛=26)	(𝑛=59)
Ccr	33.1 ± 13.7	24.5 ± 10.8	0.003 (−14.1–−3.0)
D-GFR	32.7 ± 11.2	23.7 ± 8.0	<0.001 (−13.3–−4.7)
Month 24	(𝑛=24)	(𝑛=55)
Ccr	34.2 ± 17.3	19.8 ± 9.8	<0.001 (−20.5–−8.2)
D-GFR	31.4 ± 11.2	20.2 ± 7.0	<0.001 (−15.3–−7.1)
Total decrease of renal function (mL/min/1.73 m^2) during the 2-year observation period
Ccr	12.1 ± 15.5	21.2 ± 8.7	0.002 (3.7–14.5)^#
D-GFR	11.3 ± 11.7	20.5 ± 7.7	0.001 (4.8–13.7)^#

Data were measured by the Student's 𝑡-test except ^# data by Mann-Whitney method. 𝑃<0.05 means significant differences. Ccr: creatinine clearance; D-GFR: estimated GFR for Chinese patients with type II diabetes.