Experimental Evidence of 𝜔-3 Polyunsaturated Fatty Acid Modulation of Inflammatory Cytokines and Bioactive Lipid Mediators: Their Potential Role in Inflammatory, Neurodegenerative, and Neoplastic Diseases

Figure 2

Production of anti-inflammatory lipid mediators from EPA and DHA. E-series resolvins are formed via a common precursor 18R/S-H(p)EPE, while D-series resolvins are synthesized via the common precursor 17R/S-H(p)DHA. Note that anti-inflammatory activity has been described for several of the R, as well as the S stereoisomers.