BioMed Research International / 2013 / Article / Fig 3

Review Article

Experimental Evidence of -3 Polyunsaturated Fatty Acid Modulation of Inflammatory Cytokines and Bioactive Lipid Mediators: Their Potential Role in Inflammatory, Neurodegenerative, and Neoplastic Diseases

Figure 3

Preventive effect of -3 PUFAs on the neurodegenerative Alzheimer’s disease. ALA: α-linolenic acid; DHA docosahexaenoic acid; EPA: eicosapentaenoic acid; DHA: is converted to NPD1 by 15-lipoxygenase-1 in neuronal cells. -3 PUFAs reduce AD pathology, inhibit inflammatory cytokines secretion, upregulate antiapoptotic proteins, and downregulate proapoptotic proteins expression to protect neuron, reverse age-related changes, and decrease cognitive decline for AD prevention.
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