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BioMed Research International
Volume 2013, Article ID 746858, 8 pages
Research Article

Hypoxia and Human Genome Stability: Downregulation of BRCA2 Expression in Breast Cancer Cell Lines

1Section of Medical Oncology, Department of Surgical, Oncological and Stomatological Sciences, University of Palermo, 90127 Palermo, Italy
2Phase I-Early Clinical Trials Unit, Oncology Department and Multidisciplinary Oncology Center Antwerp (MOCA), Antwerp University Hospital, 2650 Edegem, Belgium

Received 30 April 2013; Accepted 21 August 2013

Academic Editor: Dominic Fan

Copyright © 2013 Daniele Fanale et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table S1: Includes the differentially expressed genes involved in DNA damage repair (DDR) pathways in breast cancer cell lines under hypoxia. The Probe ID is the code provided by Affymetrix for each gene. All showed Signal values are in logarithm scale. The Signal value of each gene, for each experimental condition, is derived from the mean of two biological replicates. The Signal is the quantitative measure of the relative abundance of a transcript. N= Normoxia; H24= Hypoxia for 24 h; H48= Hypoxia for 48 h. Fold Change >|0.5| and P< 0.05.

  1. Supplementary Table