Clinical Study
Frequency and Characteristics of Infections Caused by Extended-Spectrum Beta-Lactamase-Producing Organisms in Neonates: A Prospective Cohort Study
Table 1
Baseline characteristics of the study cohorts.
| | Characteristics | Neonates with acquisition of infections with ESBL-producing organisms
() | Neonates with acquisition of infections with non-ESBL-producing organisms
() |
| | Median age in days at onset of sepsis (IQR) | 1 (1–7) | 3 (3–9) | | Mean gestational age in weeks (SD) | 29 (3.2) | 37 (4.2) | | Gender | | | | Male (%) | 7 (88) | 29 (75) | | Female (%) | 1 (12) | 10 (25) | | Birthweight (%) | | | | 1000 g | 3 (38) | 2 (5) | | 1000–1499 g | 3 (38) | 5 (13) | | 1500–2499 g | 2 (25) | 17 (44) | | 2500 g | 0 (0) | 15 (39) | | Preterm delivery (%) | 7 (88) | 13 (33) | | Place of birth (%) | | | | Inborn | 1 (12) | 2 (5) | | Outborn | 7 (88) | 37 (95) | | Hospital | 8 (100) | 30 (77) | | Mode of delivery (%) | | | | Vaginal delivery | 4 (50) | 26 (67) | | Cesarean | 3 (38) | 12 (30) | | Assisted delivery | 0 (0) | 1 (3) | | Breech | 1 (25) | 0 (0) | | Meconium stained amniotic fluid (%) | 1 (25) | 14 (36) | | Risk factors for sepsis (%) | 3 (38%) | 14 (36) | | Clinical signs of sepsis (%) | 5 (63) | 30 (77) | | Positive sepsis screen (%) | 3 (38) | 19 (49) | | Early onset sepsis (%) | 5 (63) | 23 (59) | | Late onset sepsis (%) | 3 (38) | 16 (41) | | Median days of hospital stay (IQR) | 61 (39–91) | 19 (11–21) | | Median days of level 3 stay (IQR) | 54 (35–77) | 11 (7–22) | | Median days of level 2 stay (IQR) | 8 (4–11) | 6 (2–8) | | Outcome (%) | | | | Expired | 2 (25) | 6 (15) |
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ESBL: extended-spectrum beta-lactamase; IQR: interquartile range; SD: standard deviation.
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