Research Article
Promoter Hypermethylation of the EMP3 Gene in a Series of 229 Human Gliomas
Table 3
Frequency of EMP3 promoter methylation according to WHO grading.
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Tumor type | Patients (n) | EMP3 hypermethylation (%) |
| WHO grade I | | | Pilocytic astrocytoma | 18 | 4 (22.2%) | WHO grade II | | | Diffuse and gemistocytic astrocytoma | 9 | 3 (33.3%) | Oligodendroglioma | 42 | 33 (78.6%) | Oligoastrocytoma | 12 | 9 (75%) | Total | 63 | 45 (71.4%) | WHO grade III | | | Anaplastic astrocytoma | 8 | 3 (37.5%) | Anaplastic oligodendroglioma | 31 | 13 (41.9%) | Anaplastic oligoastrocytoma | 8 | 5 (62.5%) | Total | 47 | 21 (44.7%) | WHO grade IV | | | pGBM | 62 | 5 (8.1%) | sGBM | 3 | 3 (100%) | Total | 65 | 8 (12.3%) |
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