Site-Specific Distribution of CD68-Positive Microglial Cells in the Brains of Human Midterm Fetuses: A Topographical Relationship with Growing Axons

Figure 4

Distribution of CD68-positive microglial cells in a brain at 22 weeks. Panel (a) (HE staining) includes the ventral hippocampus (VH) and the entorhinal cortex (ERC) at the anterior part as well as the occipital lobe and the dorsal hippocampus (DH) at the posterior part. Panels (b)–(e) correspond to squares in panel (a). Panels (b) and (d) are immunohistochemistry of glial fibrillary acidic protein, while panels (c) and (e) are that of CD68. Panels (b) and (c) (near sections) display a laminar distribution of CD68-positve cells in the occipital lobe cortex. Asterisks in panel (b) indicate a damage of section during histological procedure. Panels (d) and (e) (near sections) exhibit a cluster of CD68-positve cells facing a recess of the lateral ventricle along the ventral hippocampus. Insert in panels (c) and (e) shows the higher magnification of microglial cells. GE, germinal eminence; IC, internal capsule.