Research Article

Multiple Biomarker Panels for Early Detection of Breast Cancer in Peripheral Blood

Table 3

Pathway analysis for the best four five-marker panels.

Pathway IDPathway nameMolecule

200071Regulation of CDC42 activityBCAR3
hsa04260Cardiac muscle contractionCACNG6
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)CACNG6
hsa05410Hypertrophic cardiomyopathy (HCM)CACNG6
hsa05414Dilated cardiomyopathyCACNG6
hsa04010MAPK signaling pathwayCACNG6
194002Glucocorticoid biosynthesisCYP21A2
193993Mineralocorticoid biosynthesisCYP21A2
211976Endogenous sterolsCYP21A2
209943Steroid hormonesCYP21A2
196071Metabolism of steroid hormones and vitamins A and DCYP21A2
211897Cytochrome P450, arranged by substrate typeCYP21A2
211945Phase 1, functionalization of compoundsCYP21A2
211859Biological oxidationsCYP21A2
hsa00140Steroid hormone biosynthesisCYP21A2
556833Metabolism of lipids and lipoproteinsCYP21A2
1430728MetabolismCYP21A2
1462054Alpha-defensinsDEFA3
1461973DefensinsDEFA3
hsa05202Transcriptional misregulation in cancerDEFA3
168249Innate immune systemDEFA3
168256Immune systemDEFA3
114508Effects of PIP2 hydrolysisDGKD
hsa00561Glycerolipid metabolismDGKD
hsa04070Phosphatidylinositol signaling systemDGKD
hsa00564Glycerophospholipid metabolismDGKD
416476G alpha (q) signalling eventsDGKD
388396GPCR downstream signalingDGKD
372790Signaling by GPCRDGKD
162582Signal transductionDGKD
76002Platelet activation, signaling, and aggregationDGKD; LEFTY2
109582HemostasisDGKD; LEFTY2
1433617Regulation of signaling by NODALLEFTY2
1181150Signaling by NODALLEFTY2
114608Platelet degranulationLEFTY2
76005Response to elevated platelet cytosolic Ca2+LEFTY2
hsa04350TGF-beta signaling pathwayLEFTY2
1266738Developmental biologyLEFTY2