Anthelmintic Effects of Alkylated Diamines and Amino Alcohols against Schistosoma mansoni

Table 1

In vitro effects of alkylated diamines and amino alcohols against adult worms of S. mansoni.

Samples^b	% worm separation^e	% worm mortality^e	Significant reduction in motor activity (%)^e	log(𝑃)
Control^a	0.0	0.0	0.0
0.4% DMSO	0.0	0.0	0.0
PZQ^c	0.0	100	0.0
Compounds^d
3a	0.0	0.0	0.0	1.15
3b	50	100	0.0	1.99
3c	0.0	0.0	0.0	2.82
3d	100	100	50	3.65
3e	75	100	0.0	4.49
3f	100	100	50	3.55
3g	75	0.0	100	8.65
3h	25	100	25	4.38
4a	0.0	100	25	4.62
4b	50	100	50	5.30
4c	0.0	0.0	75	4.76
4d	0.0	100	25	4.87
10a	0.0	100	50	2.55
10b	0.0	100	50	3.39
10c	0.0	0.0	0.0	4.22
10d	0.0	100	50	5.06

aRPMI 1640; ^bperiod of incubation: 72 h; ^ctested at concentration of 10 μM; ^dtested at concentration of 100 μM; ^epercentages relative to the 8 adult worm pairs investigated. Slight was defined as a reduction in movement compared with the negative control. Significant was defined as minimal movement observed for 1 minute. Dead worm was defined when no movement was observed for at least 2 minutes of examination. log(𝑃) values were calculated using Chemdraw Ultra 12 software (trial version).