Anthelmintic Effects of Alkylated Diamines and Amino Alcohols against Schistosoma mansoni
Table 2
In vitro effects of active diamines and amino alcohols against adult worms of S. mansoni.
Samplesb
% worm separationd
% worm mortalityd
Significant reduction in motor activity (%)d
M
F
Controla
0.0
0.0
0.0
0.0
0.4% DMSO
0.0
0.0
0.0
0.0
PZQc
0.0
100
100
100
3b
12.5 μM
0.0
0.0
0.0
0.0
25 μM
0.0
0.0
0.0
0.0
50 μM
0.0
0.0
0.0
0.0
3d
12.5 μM
50
100
100
0.0
25 μM
50
100
100
0.0
50 μM
50
100
100
0.0
3e
12.5 μM
50
0.0
0.0
0.0
25 μM
100
0.0
0.0
0.0
50 μM
100
0.0
0.0
0.0
3f
12.5 μM
50
100
0.0
0.0
25 μM
50
100
0.0
0.0
50 μM
50
100
0.0
0.0
3h
12.5 μM
0.0
0.0
0.0
0.0
25 μM
0.0
0.0
0.0
0.0
50 μM
0.0
0.0
0.0
0.0
4a
12.5 μM
0.0
0.0
0.0
0.0
25 μM
0.0
0.0
0.0
0.0
50 μM
0.0
75
25
0.0
4b
12.5 μM
50
0.0
0.0
0.0
25 μM
100
0.0
0.0
0.0
50 μM
100
0.0
0.0
0.0
4d
12.5 μM
0.0
0.0
0.0
0.0
25 μM
0.0
0.0
0.0
0.0
50 μM
0.0
0.0
0.0
0.0
10a
12.5 μM
0.0
0.0
0.0
0.0
25 μM
0.0
0.0
0.0
0.0
50 μM
0.0
75
25
0.0
10b
12.5 μM
0.0
0.0
0.0
0.0
25 μM
0.0
100
0.0
0.0
50 μM
0.0
100
25
0.0
10d
12.5 μM
0.0
0.0
0.0
0.0
25 μM
0.0
100
25
0.0
50 μM
0.0
100
50
0.0
RPMI 1640; period of incubation: 72 h; tested at 10 μM; percentages relative to the 8 adult worm pairs investigated. M: males; F: females. Slight was defined as a reduction in movement compared with the negative control. Significant was defined as minimal movement observed for 1 minute. Dead worm was defined when no movement was observed for at least 2 minutes of examination.
