Molecular Characterization and In Silico Analysis of Naturally Occurring TEM Beta-Lactamase Variants among Pathogenic Enterobacteriaceae Infecting Indian Patients

Figure 4

Binding mode analysis of 3rd generation cephalosporins with bla _TEM variants in the docked complexes. Left panel shows the molecular interaction of docked bla _TEM variants with ceftazidime ((a), (d), (g), (j), (m), and (p)), middle panel shows molecular interaction with cefotaxime ((b), (e), (h), (k), (n), and (q)), and right panel shows interaction with cefpodoxime ((c), (f), (i), (l), and (o)); bla _TEM variants are represented as light orange cartoons; the three antibiotics are represented by stick, and the interacting amino acids are represented in pink colour.

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