The Effect of Thiamine and Thiamine Pyrophosphate on Oxidative Liver Damage Induced in Rats with Cisplatin

Table 1

Comparison of groups in terms of oxidant and antioxidants parameters in liver tissue.

	Groups
	CG; 𝑛: 6	TG; 𝑛: 6	TPG; 𝑛: 6	HG; 𝑛: 6
MDA (µmol/g protein)	11±1.4	9±0.5; 𝑃<0.001*	3±0.5; 𝑃<0.0001*	2.2±0.48; 𝑃<0.0001*
MPO (U/g protein)	14±2.1	12.5±2.5; 𝑃>0.05	4±0.8; 𝑃<0.0001*	3.1±0.6; 𝑃<0.0001*
tGSH (nmol/g protein)	2±0.7	2.8±0.4; 𝑃<0.05*	7±0.8; 𝑃<0.0001*	9±0.6; 𝑃<0.0001*
GST (U/g protein)	5±1.5	6.4±1.4; 𝑃>0.05	14±1.5; 𝑃<0.0001*	19±1.9; 𝑃<0.0001*
GPx (U/g protein)	7±0.9	8.2±0.7; 𝑃>0.05	17±0.6; 𝑃<0.0001*	18.7±1.9; 𝑃<0.0001*
GR (U/g protein)	3±0.6	3.7±0.5; 𝑃>0.05	11±1.5; 𝑃<0.0001*	14.5±1.1; 𝑃<0.0001*
DNA damage product 8-OHGua/Gua (pmol/L)	2.7±0.4	2.5±0.5; 𝑃>0.05	1.1±0.3; 𝑃<0.0001*	0.9±0.3; 𝑃<0.0001*

^∗𝑃≤0.05 was significant. ANOVA post hoc—the least significant difference option was used. Group data were compared against the CG group.
Notes: data are mean ± standard deviation. CG: control group; TG: thiamine 20 mg/kg + cisplatin group; TPG: TPP 20 mg/kg + cisplatin group; CG: control group; MDA: malondialdehyde; MPO: myeloperoxidase; tGSH: total glutathione; GST: glutathione S-transferase; GPx: glutathione peroxidase; GR: glutathione reductase; 𝑛: number of animals.