Figure 2: (a) Normal hepatic tissues showing hepatic strands of cells around the central vein (CV) leaving blood sinusoids (arrow). (b) Hepatic tissues pretreated with melamine show highly degree of necrosis hepatic tissues around the central veins (short arrow), highly degenerated hepatic tissues, and accumulation of granules in hepatic tissues (long arrow). Note dramatic pathological changes and accumulation of hepatic granules in most tissue and melamine crystals (MC). (c) Hepatic tissue of rats treated with honey showing normal hepatic tissues with normal hepatic strands (arrows). (d) Hepatic tissues supplemented with melamine and treated with honey show slightly necrotic hepatic tissues (short arrow) with normal hepatic strands (long arrow). ×200 (H&E stains).