BioMed Research International / 2013 / Article / Tab 3

Review Article

Cell Transplantation for Spinal Cord Injury: A Systematic Review

Table 3

In vivo transplantations of neural stem/progenitor cells.

First authorYearSCI ModelsMain graftTransplantation methodsPre-differentiation or pretreatedCombinationTissue sparingNeuronal regenerationAxonal regeneration
/remyelination
Sensory functionMotor functionCavity and/or scare formationInflammationOthers

Åkesson,
[79]
2007T8, clamp compression-ratshuman spinal cord-derived neurospheresLesion epicenter i. medu. Imp.
Webber, [80]2007C4, dorsal hemisection-ratsFetal NSCs-ratsLesion site,
rostral and caudal
i. medu.
No Imp.No Imp.Partially Imp.No Imp.High glial differentiation rate
Tarasenko, [81]2007T9-10, contusion-ratsHuman fetal NSCsLesion epicenter i. medu. Imp.Imp.Imp.
Yan, [82]2007L4 and L5 roots avulsion—nude ratsHuman fetal NSCsLesion epicenter i. medu. Imp.Imp.Synaptic contact reformation
Yasuda, [83]2011T10, contusion-miceMouse fetal NSCsLesion epicenter i. medu. Imp.Imp.Imp.Imp.
Hwang, [84]2009T9-10, contusion-ratsHuman fetal NSCsLesion epicenter and rostral
i. medu.
Olig2-transfectionImp.Imp.Imp.Imp.Imp.Imp.
Alexanian, [85]2010T8, compressed-ratsHuman fetal NPsRostral and caudal
i. medu.
Differentiated to OPCsImp.Imp.Imp.
Wang, [86]20103/4 lateral transection-ratsRats fetal NSCsRostral and caudal
i. medu.
NSCs + OECsImp.Imp.Imp.
Salazar, [87]2010T9, contusion-miceHuman fetal NSCsRostral and caudal
i. medu.
No Imp.Imp.No Imp.Imp.No Imp.

—: Not reported; Imp.: Improvement; i. medu.: intramedullary injection; SCI: spinal cord injury; NSCs: neural stem cells; NPs: neural precursors; OPCs: oligodendrocyte progenitor cells; OECs: olfactory ensheathing cells.

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