BioMed Research International / 2013 / Article / Tab 5

Review Article

Cell Transplantation for Spinal Cord Injury: A Systematic Review

Table 5

In vivo transplantations of Schwann cells.

First authorYearSCI ModelsMain graftTransplantation methodsPre-differentiation or pretreatedCombinationTissue sparingNeuronal regenerationAxonal regeneration
Sensory functionMotor functionCavity and/or scare formationInflammationOthers

Biernaskie, [107]2007T10, contusion-ratsRats SKP-SCsLesion epicenter i. medu.Imp.Imp.Imp.Imp.Imp.
Agudo, [108]2008C4, dorsal hemisection-ratsSCPs-postnatal 2d ratsRostral and caudal
i. medu.
Imp.No Imp.No Imp.Imp.Enhanced angiogenesis
Patel, [109]2010T9, contusion-ratsRats SCsLesion epicenter i. medu. Gelling matrix (laminin + collagen) + SCsImp.Imp.
Olson, [110]2009T8-9, transection-ratsRats SCsLesion epicenter i. medu. Gelling matrix + NSCs + SCsImp.Imp.No Imp.
Ban, [68]2011T9, contusion-ratsRats SCsLesion epicenter i. medu.MSCs + SCsImp.Imp.Imp.
Fouad, [111]2005T8, complete removal of a 4-mm length of spinal cord-ratsRats SCsLesion site,
rostral and caudal i. medu.
Gelling matrix + MSCs + SCsImp.Imp.Imp.
Sharp, [112]2012T9, contusion-ratsRats SCsLesion site,
i. medu.
SCs + dbCAMPImp.No Imp.

—: Not reported; Imp.: Improvement; i. medu.: intramedullary injection; SCI: spinal cord injury; SCs: Schwann cells; SKP: skin-derived precursors; SCPs: Schwann cell precursors; dbCAMP, dibutyryl CAMP; MSCs: mesenchymal stem cells.

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