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BioMed Research International
Volume 2013, Article ID 789184, 6 pages
Research Article

The Effect of Apigenin on Pharmacokinetics of Imatinib and Its Metabolite N-Desmethyl Imatinib in Rats

1The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
2School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China
3Ningbo Municipal Hospital of Traditional Chinese Medicine, Ningbo 315010, China

Received 26 June 2013; Accepted 30 October 2013

Academic Editor: Graziano Onder

Copyright © 2013 Xian-yun Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The purpose of this study was to determine the effect of apigenin on the pharmacokinetics of imatinib and N-desmethyl imatinib in rats. Healthy male SD rats were randomly divided into four groups: A group (the control group), B group (the long-term administration of 165 mg/kg apigenin for 15 days), C group (a single dose of 165 mg/kg apigenin), and D group (a single dose of 252 mg/kg apigenin). The serum concentrations of imatinib and N-desmethyl imatinib were measured by HPLC, and pharmacokinetic parameters were calculated using DAS 3.0 software. The parameters of , , , , and for imatinib in group B were different from those in group A ( ). Besides, and in groups C and D differed distinctly from those in group A as well. The parameters of and for N-desmethyl imatinib in group C were significantly lower than those in group A ( ); however, compared with groups B and D, the magnitude of effect was modest. Those results indicated that apigenin in the short-term study inhibited the metabolism of imatinib and its metabolite N-desmethyl imatinib, while in the long-term study the metabolism could be accelerated.