The Effect of Apigenin on Pharmacokinetics of Imatinib and Its Metabolite N-Desmethyl Imatinib in Rats

Table 2

The main pharmacokinetic parameters of N-desmethyl imatinib in four groups (𝑛=5).

Parameters	A	B	C	D
AUC(0--𝑡) (mg·h·L^−1)	5.977±1.626	6.335±1.105	4.797±0.602^∗∗	5.262±0.89
AUC(0--∞) (mg·h·L^−1)	6.827±2.595	6.672±0.797	5.05±0.797	5.545±0.814
MRT(0--𝑡) (h)	7.085±1.135	6.573±0.544	7.227±0.525	7.326±0.53
MRT(0--∞) (h)	9.718±4.636	7.504±0.189	8.397±1.545	8.679±1.301
𝑡(1/2)𝑧 (h)	5.495±3.92	4.083±0.436	4.906±2.093	5.376±1.495
𝑇max (h)	3.6±0.894	4.0±0.003	4.0±0.005	3.8±0.447
𝑉𝑧/𝐹 (kg·L^−1)	32.802±10.255	26.843±4.486	40.738±12.777	43.512±16.116^∗∗
CL𝑧/𝐹 (L·min^−1·kg^−1)	4.913±1.782	4.552±0.592	6.066±0.992	5.507±0.834
𝐶max (mg·L^−1)	0.678±0.147	0.797±0.073	0.547±0.091^∗∗	0.639±0.13^∗∗

∗P < 0.05 in comparison to group A; ∗∗P < 0.05 in comparison to group B.