Synergistic Effect between Cisplatin and Sunitinib Malate on Human Urinary Bladder-Cancer Cell Lines

Table 1

Combination index^a (CI) and dose reduction index (DRI) values for cisplatin and sunitinib malate combination.

Cell lines	Cisplatin; (IC50 𝜇M)	Sunitinib malate; (IC50 𝜇M)	CI50	DRI50	Interpretation
HT1376	18.2	6	0.96	Cisplatin: 5.51; Sunitinib malate: 1.5	Synergism
T24	9.44	6	0.96	Cisplatin: 2.86; Sunitinib malate: 2.19	Synergism
5637	4.12	20	0.89	Cisplatin: 1.25; Sunitinib malate: 20	Synergism

aCI₅₀ is a combination index for 50% effect, used for quantifying synergism, additivity, and antagonism.