Rikkunshito, a Japanese Kampo Medicine, Ameliorates Decreased Feeding Behavior via Ghrelin and Serotonin 2B Receptor Signaling in a Novelty Stress Murine Model

Figure 7

Effects of SB215505 or SB204741, 5-HT_2B receptor antagonists, on cumulative food intake in mice exposed to a novelty stress condition. Data are expressed as the mean ± SEM of 10–21 mice. **𝑃<0.01 when analyzed by two-factor repeated measures ANOVA. ^##𝑃<0.01 SB204741 treatment versus saline-treated mice exposed to novelty stress by Dunnett’s post hoc analysis. ^†𝑃<0.05 SB215505 treatment versus saline-treated mice exposed to novelty stress by Dunnett’s post hoc analysis.