Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2013, Article ID 795103, 9 pages
http://dx.doi.org/10.1155/2013/795103
Research Article

Serum Fetuin-A Levels Related with Microalbuminuria in Diet-Induced Obese Rats

Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China

Received 20 August 2012; Revised 29 November 2012; Accepted 4 December 2012

Academic Editor: Sharad Rastogi

Copyright © 2013 Yanyan Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Chang, S. Ryu, E. Sung et al., “Nonalcoholic fatty liver disease predicts chronic kidney disease in nonhypertensive and nondiabetic Korean men,” Metabolism: Clinical and Experimental, vol. 57, no. 4, pp. 569–576, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Targher, M. Chonchol, G. Zoppini, C. Abaterusso, and E. Bonora, “Risk of chronic kidney disease in patients with non-alcoholic fatty liver disease: is there a link?” Journal of Hepatology, vol. 54, no. 5, pp. 1020–1029, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. S. T. Hwang, Y. K. Cho, J. W. Yun et al., “Impact of non-alcoholic fatty liver disease on microalbuminuria in patients with prediabetes and diabetes,” Internal Medicine Journal, vol. 40, no. 6, pp. 437–442, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. T. Reinehr and C. L. Roth, “Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 11, pp. 4479–4485, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. J. W. Haukeland, T. B. Dahl, A. Yndestad et al., “Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies,” European Journal of Endocrinology, vol. 166, no. 3, pp. 503–510, 2012. View at Google Scholar
  6. J. H. Ix, M. G. Shlipak, V. M. Brandenburg, S. Ali, M. Ketteler, and M. A. Whooley, “Association between human fetuin-A and the metabolic syndrome: data from the heart and soul study,” Circulation, vol. 113, no. 14, pp. 1760–1767, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. N. Stefan and H. U. Haring, “The metabolically benign and malignant fatty liver,” Diabetes, vol. 60, no. 8, pp. 2011–2017, 2011. View at Google Scholar
  8. C. Buechler, J. Wanninger, and M. Neumeier, “Adiponectin, a key adipokine in obesity related liver diseases,” World Journal of Gastroenterology, vol. 17, no. 23, pp. 2801–2811, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. A. H. Kissebah, G. E. Sonnenberg, J. Myklebust et al., “Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 26, pp. 14478–14483, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Vionnet, E. H. Hani, S. Dupont et al., “Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosiome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24,” American Journal of Human Genetics, vol. 67, no. 6, pp. 1470–1480, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. A. M. Hennige, H. Staiger, C. Wicke et al., “Fetuin-A induces cytokine expression and suppresses adiponectin production,” PLoS ONE, vol. 3, no. 3, article e1765, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Sharma, S. RamachandraRao, G. Qiu et al., “Adiponectin regulates albuminuria and podocyte function in mice,” Journal of Clinical Investigation, vol. 118, no. 5, pp. 1645–1656, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Stefan, A. M. Hennige, H. Staiger et al., “α2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans,” Diabetes Care, vol. 29, no. 4, pp. 853–857, 2006. View at Google Scholar · View at Scopus
  14. R. A. DeAngelis, K. Kovalovich, D. E. Cressman, and R. Taub, “Normal liver regeneration in p50/nuclear factor κB1 knockout mice,” Hepatology, vol. 33, no. 4, pp. 915–924, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. F. Bonnet, M. Marre, J. M. Halimi et al., “Waist circumference and the metabolic syndrome predict the development of elevated albuminuria in non-diabetic subjects: the DESIR study,” Journal of Hypertension, vol. 24, no. 6, pp. 1157–1163, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Palaniappan, M. Carnethon, and S. P. Fortmann, “Association between microalbuminuria and the metabolic syndrome: NHANES III,” American Journal of Hypertension, vol. 16, no. 11, part 1, pp. 952–958, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Chen, P. Muntner, L. L. Hamm et al., “The metabolic syndrome and chronic kidney disease in U.S. adults,” Annals of Internal Medicine, vol. 140, no. 3, pp. 167–I39, 2004. View at Google Scholar · View at Scopus
  18. K. Kantartzis, J. MacHann, F. Schick, A. Fritsche, H. U. Häring, and N. Stefan, “The impact of liver fat vs visceral fat in determining categories of prediabetes,” Diabetologia, vol. 53, no. 5, pp. 882–889, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Ketteler, P. Bongartz, R. Westenfeld et al., “Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study,” Lancet, vol. 361, no. 9360, pp. 827–833, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Li, M. Xu, Y. Bi et al., “Association between higher serum fetuin-A concentrations and abnormal albuminuria in middle-aged and elderly Chinese with normal glucose tolerance,” Diabetes Care, vol. 33, no. 11, pp. 2462–2464, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Yilmaz, O. Yonal, R. Kurt et al., “Serum fetuin A/α2HS-glycoprotein levels in patients with non-alcoholic fatty liver disease: relation with liver fibrosis,” Annals of Clinical Biochemistry, vol. 47, no. 6, pp. 549–553, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. J. M. Brix, H. Stingl, F. Höllerl, G. H. Schernthaner, H. P. Kopp, and G. Schernthaner, “Elevated fetuin-A concentrations in morbid obesity decrease after dramatic weight loss,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 11, pp. 4877–4881, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Sharma, “The link between obesity and albuminuria: adiponectin and podocyte dysfunction,” Kidney International, vol. 76, no. 2, pp. 145–148, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Savino, P. Pelliccia, F. Chiarelli, and A. Mohn, “Obesity-related renal injury in childhood,” Hormone Research in Paediatrics, vol. 73, no. 5, pp. 303–311, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Pavan, R. Ranganath, A. PChudhari, and M. Shetty, “Obesity as an independent risk factor for the development of microalbuminuria,” Nephro-Urology Monthly, vol. 3, no. 4, pp. 276–279, 2011. View at Google Scholar
  26. G. Marchesini, S. Moscatiello, S. di Domizio, and G. Forlani, “Obesity-associated liver disease,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 11, supplement 1, pp. s74–s80, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Wang, Z. Mingyan, K. S. L. Lam, and A. Xu, “Protective roles of adiponectin in obesityrelated fatty liver diseases: mechanisms and therapeutic implications,” Arquivos Brasileiros de Endocrinologia e Metabologia, vol. 53, no. 2, pp. 201–212, 2009. View at Google Scholar · View at Scopus
  28. L. A. Videla, G. Tapia, R. Rodrigo et al., “Liver NF-κB and AP-1 DNA binding in obese patients,” Obesity, vol. 17, no. 5, pp. 973–979, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. L. Li, L. Chen, L. Hu et al., “Nuclear factor high-mobility group box1 mediating the activation of toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice,” Hepatology, vol. 54, no. 5, pp. 1620–1630, 2011. View at Google Scholar
  30. S. Dasgupta, S. Bhattacharya, A. Biswas et al., “NF-κB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance,” Biochemical Journal, vol. 429, no. 3, pp. 451–462, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. D. Pal, S. Dasgupta, R. Kundu et al., “Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance,” Nature Medicine, vol. 18, no. 8, pp. 1279–1285, 2012. View at Google Scholar
  32. P. A. Sarafidis and L. M. Ruilope, “Insulin resistance, hyperinsulinemia, and renal injury: mechanisms and implications,” American Journal of Nephrology, vol. 26, no. 3, pp. 232–244, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. G. Targher, F. Marra, and G. Marchesini, “Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon?” Diabetologia, vol. 51, no. 11, pp. 1947–1953, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. R. S. Rosenson, “Effect of fenofibrate on adiponectin and inflammatory biomarkers in metabolic syndrome patients,” Obesity, vol. 17, no. 3, pp. 504–509, 2009. View at Publisher · View at Google Scholar · View at Scopus