Figure 6: IL-6 and IL-8 release from the ABB model exposed to metal oxides NPs (25 μg/mL) at day 12 of culture. The release of IL-6 is significantly increased by CuO and TiO2 NPs in the apical compartment (a) while IL-8 is significantly increased in the apical compartment only after treatment with CuO NPs. (b) *Statistically different from control , ANOVA.