Research Article
Optimization Studies on Compression Coated Floating-Pulsatile Drug Delivery of Bisoprolol
Table 5
Formulation of batches containing Polyox WSR205 and Polyox N12K as variables according to the 32 full factorial design.
| | Formulation no. | Polyox WSR205 (mg) | Polyox WSR N12K (mg) | Sodium bicarbonate (mg) | Citric acid (mg) | Core tablet (mg) | Calcium diphosphate (mg) |
| | F10 | 45 | 65 | 50 | 20 | 75 | 40 | | F11 | 45 | 75 | 50 | 20 | 75 | 30 | | F12 | 45 | 85 | 50 | 20 | 75 | 20 | | F13 | 55 | 65 | 50 | 20 | 75 | 30 | | F14 | 55 | 75 | 50 | 20 | 75 | 20 | | F15 | 55 | 85 | 50 | 20 | 75 | 10 | | F16 | 65 | 65 | 50 | 20 | 75 | 20 | | F17 | 65 | 75 | 50 | 20 | 75 | 10 | | F18 | 65 | 85 | 50 | 20 | 75 | — |
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