Optimization Studies on Compression Coated Floating-Pulsatile Drug Delivery of Bisoprolol

Table 6

Evaluation of floating-pulsatile release tablet (F10–F18).

Formulation no.	Tablet weight; (mg)	Tablet thickness; (mm)	% drug content	Hardness; (Kg/cm^2)	Swelling index	Buoyancy lag time; (sec.)	% drug release
F10	294.12±1.56	2.55±0.07	98.45±0.56	7.5±0.13	188.45±2.34	108±2	99.49±1.32
F11	297.29±2.14	2.64±0.04	97.27±0.75	7.8±0.25	192.66±3.75	109±3	99.23±0.74
F12	298.54±1.35	2.58±0.03	98.17±1.34	7.7±0.06	201.56±2.56	113±5	99.30±0.96
F13	295.23±0.95	2.52±0.05	97.96±0.78	8.1±0.15	206.45±1.34	102±3	99.89±2.01
F14	292.11±1.23	2.44±0.08	98.62±1.56	7.4±0.08	210.55±3.13	116±2	83.60±0.82
F15	294.78±0.87	2.63±0.02	97.39±0.50	7.9±0.12	222.44±1.57	115±2	80.94±0.95
F16	297.89±0.98	2.68±0.10	97.19±2.34	8.2±0.34	226.45±2.18	111±3	75.21±1.74
F17	291.55±1.34	2.57±0.04	98.82±0.34	7.6±0.26	231.61±3.56	110±5	66.96±1.98
F18	298.78±2.15	2.62±0.03	96.98±2.78	7.8±0.13	239.77±2.15	119±5	59.94±2.02