A Lys49 Phospholipase , Isolated from Bothrops asper Snake Venom, Induces Lipid Droplet Formation in Macrophages Which Depends on Distinct Signaling Pathways and the C-Terminal Region
MT-II-induced LDs are morphologically distinct cytoplasmic sites. (a) Control macrophages with typical morphology. (b) and (c) Macrophages incubated with MT-II (0.8 μM) for 1 h showing light and large cytoplasmic lipid droplets (LDs). Also, an enlarged ER can be observed in MT-II-stimulated cells. N: nucleus.
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