Effects of Anesthesia and Species on the Uptake or Binding of Radioligands In Vivo in the Göttingen Minipig

Table 4

Kinetic parameter values (mean ± SD) from the UGA analysis for SCH23390 studies (𝑁=6) using the two anesthetic compounds for the average of 3 nonstriatal regions (thalamus, frontal, and temporal cortices) and striatum.

	Ki* (1/min)	k loss (1/min)	Ki*/k loss
Non striatal regions
Isoflurane	0.0268±0.008	0.032±0.011	0.84
Propofol	0.0166±0.007^∗	0.023±0.010	0.72
Striatum
Isoflurane	0.0465±0.018	0.009±0.004	5.16
Propofol	0.0298±0.008^∗	0.010±0.003	2.98*

^∗𝑃<0.05.