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BioMed Research International
Volume 2013, Article ID 809234, 8 pages
Clinical Study

Effects of Water Extracts of Graptopetalum paraguayense on Blood Pressure, Fasting Glucose, and Lipid Profiles of Subjects with Metabolic Syndrome

1Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
2School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
3Center for Education and Research on Geriatrics and Gerontology, Chung Shan Medical University, Taichung 40201, Taiwan
4Department of Health Food, Chung Chou University of Science and Technology, Changhua 51003, Taiwan
5School of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan
6Department of Nutrition, Chung Shan Medical University Hospital, Taichung 40201, Taiwan

Received 16 September 2013; Accepted 29 October 2013

Academic Editor: Esteban Martinez

Copyright © 2013 Chi-Hua Yen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study was aimed to investigate the effects of water extracts of Graptopetalum paraguayense (WGP, 4 g/d) on blood pressure, blood glucose level, and lipid profiles in subjects with metabolic syndrome (MS). Participants with MS ( ) were randomly assigned to the placebo ( ) and WGP groups ( ), and the intervention was administered for 12 weeks. Systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting glucose (FG), lipid profiles (total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein (HDL-C)), and antioxidant enzymes activities (catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)) were measured. Forty-two subjects completed the study (placebo, ; WGP, ). FG, SBP, and LDL-C levels were significantly lower and HDL-C level and antioxidant enzymes activities (CAT and SOD) were significantly higher after WGP supplementation. Blood pressure, FG, and lipid profiles were significantly correlated with antioxidant enzymes activities after supplementation ( ). The present study demonstrated a significant reduction in blood pressure, blood glucose, and lipid profiles and an increase in antioxidant enzymes activities in subjects with MS after WGP supplementation. Taken together, the antioxidative capacity of WGP might exert a beneficial effect on MS. This trial is registered with NCT01463748.