Table 2: Genes down regulated during HBV induced hepatocellular carcinoma

Genes Down regulated during HCC:
GeneGene nameActivated byFunctionReference

BIDBH3 interacting domainHBx protein Cell death regulation [106]
P53Protein 53HBxTumor suppressor[107]
p21WAF1Protein 21HBxStress response, acts with p53[107]
IGFBP3Insulin-like growth factor-binding protein 3HBx[107]
CASP8Caspase 8HBVApoptosis-related cysteine peptidase[89]
CDKN1A/p21Cyclin-dependent kinase inhibitor 1AHBVInhibits the activity of cyclin-CDK2[107]
DLC1Deleted in liver cancer 1HBVTumor suppressor, cell growth, and proliferation[108]
FADDFas-associated protein with death domainHBVAdaptor molecule that bridges the Fas-receptor[109]
IGFBP1Insulin-like growth factor-binding protein 1HBVTumor suppressor[110]
ITGB1Integrins beta 1HBVEmbryogenesis, hemostasis, tissue repair, immune response[111]
HhipHh-interacting proteinHBVModulates hedgehog signaling[112]
PTENHBVApoptosis, cell movement[113]
RB1Retinoblastoma 1HBVOncogenic, tumor suppressor[114]
SMAD4HBVTransmitting chemical signal, regulates cell growth and division[115]
SOCS1Suppressor of cytokine signaling 1HBVNegative regulator in TNF-induced inflammation and activation of c-jun N-terminal kinase[116]
SOCS3Suppressor of cytokine signaling 3HBV[117]
TGFBR2Transforming growth factor, beta receptor IIHBVTransmits signals, stimulation of cell growth and division, differentiation[118]
CDKN2ACyclin-dependent kinase inhibitor 2AHBV and HCVCell cycle control, tumor suppressor gene[119]